Synthesis of aromatic thio-acid esters of 2-thiophenylethanol and exploring some of their biological activities
| dc.contributor.author | Hawi, Maram | |
| dc.date.accessioned | 2022-09-25T05:32:52Z | |
| dc.date.available | 2022-09-25T05:32:52Z | |
| dc.date.issued | 2020-01-15 | |
| dc.description.abstract | Four compounds of thio-acid esters were prepared from the reaction of benzoic acid derivatives including 2-hydroxy, 3-hydroxy, 4-hydroxy benzoic acid with 2-thiophenylethanol. The structures of these thioesters were established by Fourier Transform Infrared (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR) and C13. The aromatic thioesters were tested for their anti-oxidant, anti-fungal, anti-bacterial, anticancer anti-diabetic and anti-obesity activities. The compounds activity as antioxidants in DPPH was about (IC50=30µg/ml), the same value for Gallic acid. The compounds were tested also for their antibacterial activity against: (Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Proteus Vulgaris, Enterococcus Faecium, Pseudomonas Aeruginosa, MRSA, and Candida Albicans) and showed MIC value average (3.125-6.25mg\ml), the MIC average for ampicillin antibiotic (0.001-3.125 mg\ml). While the cytotoxic property will be assessed on MCF-7, human carcinoma cells and showed the average (G2-M phase: 21.83, 8.13, 10.66, 14, 3.66). Moreover, for amylase (IC50 = 10) which is the same as Acarbose. | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.11888/17510 | |
| dc.publisher | Maram Hawi | en_US |
| dc.subject | Synthesis of aromatic thio-acid esters of 2-thiophenylethanol and exploring some of their biological activities | en_US |
| dc.supervisor | Nidal Jaradat + Ahmad Khasati | en_US |
| dc.title | Synthesis of aromatic thio-acid esters of 2-thiophenylethanol and exploring some of their biological activities | en_US |
| dc.type | Thesis | en_US |