Synthesis of aromatic thio-acid esters of 2-thiophenylethanol and exploring some of their biological activities
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Date
2020-01-15
Authors
Hawi, Maram
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Publisher
Maram Hawi
Abstract
Four compounds of thio-acid esters were prepared from the reaction of benzoic acid derivatives including 2-hydroxy, 3-hydroxy, 4-hydroxy benzoic acid with 2-thiophenylethanol. The structures of these thioesters were established by Fourier Transform Infrared (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR) and C13. The aromatic thioesters were tested for their anti-oxidant, anti-fungal, anti-bacterial, anticancer anti-diabetic and anti-obesity activities. The compounds activity as antioxidants in DPPH was about (IC50=30µg/ml), the same value for Gallic acid. The compounds were tested also for their antibacterial activity against: (Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Proteus Vulgaris, Enterococcus Faecium, Pseudomonas Aeruginosa, MRSA, and Candida Albicans) and showed MIC value average (3.125-6.25mg\ml), the MIC average for ampicillin antibiotic (0.001-3.125 mg\ml). While the cytotoxic property will be assessed on MCF-7, human carcinoma cells and showed the average (G2-M phase: 21.83, 8.13, 10.66, 14, 3.66). Moreover, for amylase (IC50 = 10) which is the same as Acarbose.
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Synthesis of aromatic thio-acid esters of 2-thiophenylethanol and exploring some of their biological activities