ASSOCIATION BETWEEN VITAMIN D-BINDING PROTEIN AND VITAMIN D3 LEVEL IN HEMODIALYSIS PATIENTS
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Date
2024-03-07
Authors
Hamadneh, Ayat
Journal Title
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Publisher
An-Najah National University
Abstract
Background: Vitamin D deficiency is a common problem among patients with end-stage renal failure who undergo dialysis, which requires extensive research and interventions due to its widespread repercussions in the body. Understanding the physiology of vitamin D, as well as identifying factors contributing to its deficiency, has been the focus of research. In addition, vitamin D binding protein (VDBP) and its potential role in influencing vitamin D levels have been explored, with the hope of finding therapeutic interventionsObjectives: For the time being, there is a limited research about the relationship between VDBP and other vital signs, especially among dialysis patients in Palestine. This study aimed to treat this gap by investigating the relationship between VDBP and vitamin D levels in dialysis patients.
Methodology: A prospective study, conducted among hemodialysis patients at Al-Najah hospital, Nablus, Palestine, over 10 months. The patients were treated with different doses of Alfacalcidol and Cholecalciferol for a total of 17 weeks. VDBP measured by specific sandwich utilizing enzyme-linked immunosorbent assay (ELIZA) technique by R&D used polyclonal rabbit anti-VDBP antibodies, vitamin D is also measured by ELIZA technique, both of them defined before and after course of tretment. Results: The results indicated that after a course of vitamin D treatment, VDBP levels decreased significantly while vitamin D levels increased significantly, with no correlation between them. These results were consistent with previous research that showed no significant relationship between VDBP and vitamin D levels in different population groups.Demographic variables such as age and gender did not show a conclusive association with VDBP levels among dialysis patients, which is in contrast to results from other studies. In addition, there was no significant relationship between VDBP levels and the results of other laboratory tests such as albumin, calcium, phosphorus, and parathyroid hormone (PTH).
Conclusion: Overall, this study underscores the importance of vitamin D treatment in dialysis patients and highlights the need for further research to fully understand the role of VDBP in vitamin D metabolism and its implications for clinical management.
Keywords: Vitamin D, Vitamin D binding protein, End stage renal disease, Hemodialysis patients