Formulation and Stability Evaluation of Ciprofloxacin Topical Preparation

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An-Najah National University
With increment the number of infections resistance to antibiotics and life threatening causes many researchers work on developing alternative approaches and manufacturing new drug delivery systems to traverse the disadvantages of the conventional antibiotics. The aim of this study was to encapsulate the ciprofloxacin HCl in three different surfactants such as anionic surfactant (Sodium Lauryl Sulfate), cationic surfactant (Cetrimide) and nonionic surfactant (Tween 20). The encapsulation may in one hand help improving penetration behavior of the ciprofloxacin and on the other hand reduce the used doses. The other vital role of this research was the formulation of three stable encapsulated topical dosage forms (ciprofloxacin HCl gels) in order to treat topical infections. The encapsulation of ciprofloxacin HCl lead to successful conspicuous increasing in ciprofloxacin loading with potentially more soluble pattern. Fortunately, the in vitro release results revealed that about almost 90% of the loaded ciprofloxacin HCl was released at pH 5.5 in the first 2 hours. The prepared three gels differentiated as stable, clear and homogeneous formulation with good rheology characteristics. Moreover, improvement in the results of the antibacterial activity manifest that the newly encapsulated ciprofloxacin had better antibacterial activity against S. aureus and P. aeruginosa than ciprofloxacin alone.