Recycling of Liquid Effluents from HPLC Devices in Pharmaceutical Industry

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Zubidi, Eman
Odeh, Hadi
Zaid Alkeelani, Mohammed
Odeh, Tasneem
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The main objective of this project is to recycle acetonitrile- methanol -water mixture from the High Pressure Liquid Chromatography (HPLC) waste in the pharmaceutical sector. The recycling process always has economic benefits and helps in protecting the environment. For this purpose, the literature was reviewed and the most appropriate recycling methods were investigated. Of these methods, biological treatment and degradation, batch extractive distillation, and azeotrope distillation are summarized. Unfortunately, the literature doesn't’ provide enough information, since most of the processes are patented. As a result, other rational techniques were investigated in order to find the most efficient and applicable solution for this problem. These techniques were crystallization, adsorption using clay, distillation, extraction and converting the mixture to a fuel are proposed. When the crystallization technique was investigated it was found that it is not applicable method to recycle or separate the waste components because of its low freezing points and it was not possible to reach these low temperatures because of the lack of the appropriate equipments, The adsorption of the waste component by using clay was not applicable because the clay adsorb all of the mixture component. The type of distillation was available is simple distillation and it was not an appropriate method because of the creation of azeotropic point. Extraction process was investigated by using different solvents such as; kerosene, soya bean oil, fuel produced from tire oil and biodiesel. it was found that the solubility of waste component by using kerosene, soya bean oil, fuel produced from tire oil was not useful for the main purpose but the extraction by using biodiesel as a solvent was the most appropriate method because acetonitrile and methanol are soluble in biodiesel and the water was not As a result of using biodiesel as a solvent, a liquid-liquid extraction column was designed with a height of 60 cm. and diameter of 4 cm with a packing material of 1 cm diameter, and the column were operated with different flow rates of waste and biodiesel to find out the most appropriate flow rates of biodiesel and waste to find out the maximum extraction ratio for the waste which was equal to 0.15 mL per second and 2.5 mL per second for waste and biodiesel respectively. The biodiesel which was used in the extraction process contains methanol and acetonitrile can be distilled to separate the acetonitrile and methanol mixture from the biodiesel in order to reuse the biodiesel for reducing the required amount of biodiesel for the process, also for recovery of the methanol and acetonitrile mixture for using it in future application such as adding it to different types of fuel.