Design and Development of Microemulsion Drug Delivery System for Improvement of Oral Bioavailability

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Mohamad Shanaa
Bassem Abo-3amer
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The aim of the present study was to design o/w microemulsion of Glimepiride and to study its dissolution behavior by raising its solubility. Pseudoternary phase diagrams were developed at different ratios of Tween 80 to determination the microemulsion zone.   Glimepiride exhibits very poor solubility (at 370C, <0.004 mg/ml) which may cause poor dissolution and unpredicted bioavailability for that the Solubility of Glimepiride at the O/W microemulsion was increased by 1625 times to that of pure water . Three Microemulsion system with tween 80 as surfactant are designed and developed for oral delivery of glimepiride, these systems are:       Ethyl Oleate / Turmic oil /  Tween 80 / MilliQ water       Ethyl Oleate / Clove Oil /  Tween 80 / MilliQ water       Oleic acid / Tween 80 / MilliQ water   Microemulsions are excellent candidates as potential drug delivery systems because of their improved drug solubilization, long shelf life, and ease of preparation and administration. Conclude that microemulsion could be used as a possible alternative to traditional oral drug formulation This report include on the specification of microemulsion , advantage and dis-advantage, the parts of microemulsion , types of drug delivery, result of our experiments and many other things.