Preparation and Evaluation of the Activities of New Mono-Cation phen- Cu(II) Complexes Toward Cancer Cells
| dc.contributor.advisor | وراد, إسماعيل | |
| dc.contributor.author | دقة, ملاك زياد احمد | |
| dc.date.accessioned | 2018-12-06T08:17:51Z | |
| dc.date.available | 2018-12-06T08:17:51Z | |
| dc.date.issued | 2017-12-17 | |
| dc.description.abstract | Water soluble mono-cationic copper(II) complexes of the general formula [Cu(NO2-phen)2Br]Br, (NO2-phen = 5-nitro-1,10-phenantholine) and [Cu(phen)2Br]Br were prepared in good yield under ultrasonic irradiation. The desired complexes were isolated as bromide salts and identified by MS, EA, UV-visible, TG/DTA, FT-IR and XRD. The single-crystal X-ray diffraction and Hirschfeld analysis revealed distorted square pyramidal geometry around the Cu(II) center. The geometry of the [Cu(NO2-phen)2Br]+ complex was fully optimized with ab-initio methods and (DFT/B3LYP) density functional theory, then structural parameters were compared to the XRD data. The Solvatochromism of [Cu(NO2-phen)2Br]Br complex was investigated in several polar solvents. Absorption and viscosity titration studies concluded that the [Cu(NO2-phen)2Br]Br complex is a very good CT-DNA binder. | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.11888/14017 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | An-Najah National University | en_US |
| dc.title | Preparation and Evaluation of the Activities of New Mono-Cation phen- Cu(II) Complexes Toward Cancer Cells | en_US |
| dc.title.alternative | تحضير وتقييم النشاطات لمجموعة جديدة من معقدات النحاس الثنائي-فينانثرولين باتجاه محاربة خلايا السرطان | en_US |
| dc.type | Thesis | en_US |