Preparation and Evaluation of the Activities of New Mono-Cation phen- Cu(II) Complexes Toward Cancer Cells
دقة, ملاك زياد احمد
An-Najah National University
Water soluble mono-cationic copper(II) complexes of the general formula [Cu(NO2-phen)2Br]Br, (NO2-phen = 5-nitro-1,10-phenantholine) and [Cu(phen)2Br]Br were prepared in good yield under ultrasonic irradiation. The desired complexes were isolated as bromide salts and identified by MS, EA, UV-visible, TG/DTA, FT-IR and XRD. The single-crystal X-ray diffraction and Hirschfeld analysis revealed distorted square pyramidal geometry around the Cu(II) center. The geometry of the [Cu(NO2-phen)2Br]+ complex was fully optimized with ab-initio methods and (DFT/B3LYP) density functional theory, then structural parameters were compared to the XRD data. The Solvatochromism of [Cu(NO2-phen)2Br]Br complex was investigated in several polar solvents. Absorption and viscosity titration studies concluded that the [Cu(NO2-phen)2Br]Br complex is a very good CT-DNA binder.