Synthesis, Spectral, Thermal, Electrochemical Characterization of New Family of Semi-Octahedral Diamine / Copper (II) Complexes and their Biological Activities
Date
2017-06-20
Authors
Abd Al-Ghani, Bahaa
Journal Title
Journal ISSN
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Publisher
An-Najah National University
Abstract
Our research focuses on synthesis of novel compounds which are expected to be excellent donating compounds in coordination chemistry besides synthesis of their complexes.
Four new hydrated monocationCu(II) complexes with 1,3-propylenediamine and1,2-ethylenediamine with chloro or bromo ligands were prepared in acceptable yield. The complexes were spectrally characterized by (IR, UV-visible, and TOF-MS) as well as by thermal (TG/DTA) and elemental analysis. The three dimensional structure for complexes 2,4were proved by X-ray diffraction studies, which show the Cu(II)is coordinated by four nitrogen atoms of the base ligand and one bromide ion or chloride ion. In the crystal structure, molecules are connected through intermolecular dipole interactions of the type N---H...Br and hydrogen bond N---H…O. Additionally, an intramolecular hydrogen bond of the type C---H…Br is observed; these interactions lead to a three dimensional architectural packing in the crystal structure. Hirschfeld surfaces computational method was used to figure out the intercontacts in the crystal structure, the data showed that intercontacts of the type H…H (52.8 %), H…Br (32.7 %), H…O (12.4 %) and Br…O (2.1 %) were observed and quantified. Antitumor activity of the desired complexes was evaluated. The results revealed high antitumor activity against several types of cancer cells.