Synthesis, Spectral, Thermal, Electrochemical Characterization of New Family of Semi-Octahedral Diamine / Copper (II) Complexes and their Biological Activities

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dc.contributor.advisorWarad, Ismail
dc.contributor.authorAbd Al-Ghani, Bahaa
dc.date.accessioned2018-02-27T10:27:30Z
dc.date.available2018-02-27T10:27:30Z
dc.date.issued2017-06-20
dc.description.abstractOur research focuses on synthesis of novel compounds which are expected to be excellent donating compounds in coordination chemistry besides synthesis of their complexes. Four new hydrated monocationCu(II) complexes with 1,3-propylenediamine and1,2-ethylenediamine with chloro or bromo ligands were prepared in acceptable yield. The complexes were spectrally characterized by (IR, UV-visible, and TOF-MS) as well as by thermal (TG/DTA) and elemental analysis. The three dimensional structure for complexes 2,4were proved by X-ray diffraction studies, which show the Cu(II)is coordinated by four nitrogen atoms of the base ligand and one bromide ion or chloride ion. In the crystal structure, molecules are connected through intermolecular dipole interactions of the type N---H...Br and hydrogen bond N---H…O. Additionally, an intramolecular hydrogen bond of the type C---H…Br is observed; these interactions lead to a three dimensional architectural packing in the crystal structure. Hirschfeld surfaces computational method was used to figure out the intercontacts in the crystal structure, the data showed that intercontacts of the type H…H (52.8 %), H…Br (32.7 %), H…O (12.4 %) and Br…O (2.1 %) were observed and quantified. Antitumor activity of the desired complexes was evaluated. The results revealed high antitumor activity against several types of cancer cells.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11888/13209
dc.language.isoen_USen_US
dc.publisherAn-Najah National Universityen_US
dc.titleSynthesis, Spectral, Thermal, Electrochemical Characterization of New Family of Semi-Octahedral Diamine / Copper (II) Complexes and their Biological Activitiesen_US
dc.title.alternativeتحضير وتشخيص طيفي وحراري وكهروكيميائي لعائله جديدة من معقدات النحاس /ثنائي الأمين مع تقييم نشاطها ضد الخلايا السرطانيةen_US
dc.typeThesisen_US
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