PROGNOSIS IN RELATION TO HIGH SENSITIVITY CARDIAC TROPONIN T FOR PATIENTS WITH MYOCARDIAL INFRACTION WITH NON-OBSTRUCTIVE CORONARY ARTERIES- A SINGLE CENTER STUDY
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Date
2024-09-26
Authors
AbuZant, Azza
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Publisher
An-Najah National University
Abstract
General background: myocardial infarction is a general term of a heart attack, it can be caused by several medical conditions and one of these condition is myocardial infarction with non-obstructive coronary (MINOCA) which is a recent cause of myocardial infarction, while most studies focused on other major causes of MI such as myocardial infarction with obstructive coronary artery disease, so our goal in this study is to assess the investigation over a period of at least one-year of high sensitivity cardiac troponin T (hs-cTnT) levels in patients with MINOCA and compare them with the level of (hs-cTnT) levels in patients with myocardial infarction with obstructive coronary artery disease to be used as a prognostic marker for at least MINOCA patients.
Aim of the study: Briefly this study aims to determine the prognostic value of high sensitivity cardiac troponin T for patients with non-obstructive coronary arteries with comparison of patients with myocardial infarction with coronary artery disease.
Methodology: A descriptive retrospective cohort study was between patients who were admitted at cardiology department at ANNUH in Nablus. The sample was collected by stratified sampling method and a population of 3642 patients were included and the required samples were taken from this population and it was conducted from June 2021 to December 2023, the patient’s information was collected from the ANNUH special program, a list of information collecting sheet was manually made and also depending on Excel paper sheet to collect specific information about these patients to be used for data collection. The total number of included patients was 118 myocardial infarction with obstructive coronary arteries patients and 1011 myocardial infarction with obstructive coronary arteries patients from a total population of 3642.
Statical analysis: after SPSS analysis results high sensitivity cardiac troponin T levels in myocardial infarction with non-obstructive coronary artery patients predicted all-cause mortality with a hazard ratio of 1.39 [95% CI 0.99-1.6]), cardiovascular mortality with a hazard ratio of 1.24 [95% CI 1.18-1.29]) and major cardiovascular events with a hazard ratio of 1.31 [95% CI 1.18-2.51]). Hs-cTnT predicted readmissions for heart failure (hazard ratio of 1.51 [95% CI 1.14-2.00]). After doing the statical analysis it’s been proven that hs-cTnT was a prognostic biomarker in patients with myocardial infarction with non-obstructive coronary arteries compared to patients with myocardial infarction with obstructive coronary arteries.
Conclusion: the conclusion if this study stated that (hs-cTnT) levels in patients with (MINOCA) are strong and independent predictors of the future outcomes and are very important for risk assessment for patients with (MI-CAD).