Determination of A New Synthetic Pyrido-Pyrimidine by Adsorptive Cathodic Stripping Voltammetry

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Date
2000
Authors
Iqab G. Y. Naji
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Adsorptive cathodic stripping voltammetric (AdCSV) technique was used to determine trace amounts of (7—Bromo-2, 3—tetramethylene pyrido [1,2,a] pyrimidine -4-one), BTP, anew pyrimidine synthetic derivative. This compound is a potential drug which may be used to cure diseases such as cancer. The determination was very sensitive and linearity between peak current and concentration was studied in the range 5x10⁻⁸ to 2x10⁻⁶ M with peak potential at about -0.8V, The detection limit is about 5x10⁻⁸ M after 30 s accumulation time at -0.4V accumulation potential. The measurements have been taken in acetate buffer of pH 4.5 versus Ag/AgCl reference electrode. The RSD % at 2x10⁻⁷ M level didn't exceed 3.0% (six determinations). The optimum conditions for such determination was investigated and the addition of copper, nickel and some other metal ions did not affect the peak current. A calibration curve was built up at the optimum conditions and the method is useful to determine very low concentrations of this newly synthesized substance.
Adsorptive cathodic stripping voltammetric (AdCSV) technique was used to determine trace amounts of (7—Bromo-2, 3—tetramethylene pyrido [1,2,a] pyrimidine -4-one), BTP, anew pyrimidine synthetic derivative. This compound is a potential drug which may be used to cure diseases such as cancer. The determination was very sensitive and linearity between peak current and concentration was studied in the range 5x10⁻⁸ to 2x10⁻⁶ M with peak potential at about -0.8V, The detection limit is about 5x10⁻⁸ M after 30 s accumulation time at -0.4V accumulation potential. The measurements have been taken in acetate buffer of pH 4.5 versus Ag/AgCl reference electrode. The RSD % at 2x10⁻⁷ M level didn't exceed 3.0% (six determinations). The optimum conditions for such determination was investigated and the addition of copper, nickel and some other metal ions did not affect the peak current. A calibration curve was built up at the optimum conditions and the method is useful to determine very low concentrations of this newly synthesized substance.
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