THE CORRELATION BETWEEN INTERLEUKIN-6 AND BONE MINERAL DENSITY AMONG HEMODIALYSIS PATIENTS IN PALESTINE
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Date
2024-10-13
Authors
Zakarneh, Siwar
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Publisher
An-Najah National University
Abstract
Background Chronic kidney disease (CKD) is a significant public health challenge worldwide. CKD and End Stage Renal Disease (ESRD) have systemic effects on the body, including cardiovascular diseases (CVDs), hematologic problems, metabolic abnormalities, and bone diseases, which are then referred to as chronic kidney disease-mineral and bone disorders (CKD-MBD). Therefore, monitoring bone density in chronic kidney disease patients is very crucial. This study aims to identify the association between IL-6 and clinical parameters with Bone density in chronic kidney disease patients. This study aims to find out the association between IL-6 and the severity of bone mineral disease on (Dual-energy X-ray absorptiometry) DEXA scan to measure IL-6 as a new marker for bone remodelling and reabsorption in renal osteodystrophy patients as determined by bone mineral density (BMD) at different sites and to help monitor bone remodelling and reabsorption in renal osteodystrophy patients.
Methods A cross-sectional study was conducted among ESRD patients in An-Najah National University Hospital, Nablus, Palestine dialysis unit. A total number of 138 samples were collected from the patients between April 2022 and May 2022. Patient samples were frozen at -80°C. Then, sample was thawed, and the interleukin-6 cytokine was tested using the manual ELISA method (DRG Instruments). The sensitivity of this ELISA kit is 2 pg\dL. A dual-energy X-ray absorptiometry (DEXA) scan was used to evaluate BMD, and a T-score represents the result. SPSS were used to analyze data.
ResultsThe results indicate that most patients included in the study had osteoporosis with a prevalence of 60%, 53%, 47% and 50%, 44.7, and 33.8 for osteopenia at the spine, hip, and neck, respectively.
IL-6 is normal within our participants, and there is no relationship between IL-6 and Dexa scan. On the other hand, this study revealed that there is a correlation between IL-6 and albumin (p value< 0.001), ferritin (p-value = 0.011), iron (p-value = 0.008), transferrin saturation (p-value = 0.013), and hemoglobin concentration (p-value = 0.018).
Patients who had more CVDs significantly had higher IL-6 than patients who had not. In addition, the IL-6 value for patients with only CVDs is higher than that for those with DM or both CVD and DM and higher than that for those with none of them.
ConclusionThe main promising finding is that Palestinian CKD patients have low bone density and elevated levels of IL-6, which were linked with low albumin, iron, transferrin saturation, and hemoglobin but increased ferritin concentration. It also demonstrated that CVDs could be related to high IL-6 concentration in those patients.