FORMULATION AND CHARACTERIZATION OF HERBAL OIL EXTRACTS LOADED ON NANOTRANSFERSOMES TRANDERMAL DELIVERY SYSTEM

Abstract

Background: Skin problems such as eczema, psoriasis, burns, and skin cancer are among the most common health issues affecting many people. Efforts have been ongoing to find ways to alleviate and treat these problems, and the use of nanoparticles such as ethosome loaded with active ingredients like luteolin and herbal oils (black seed oil, sesame seed oil, and pomegranate seed oil) is one option. Method:Tranethosome was developed, consisting of the aforementioned herbal oils and luteolin in varying proportions, and several formulations were created. F22 proved to be the best, and numerous tests were conducted to examine its effectiveness, including antioxidant, SPF, pH, morphology, particle size, antimicrobial, cell viability, anticancer, COX inhibitor, FTIR, entrapment efficiency, and stability test. Result: Regarding the results of these tests, F22 possessed a strong antioxidant activity close to that of Trolox, a high SPF of approximately 17, and a pH suitable for dermatological use between 5 and 5.5. It had a spherical shape and a size of 310 nm, exhibited moderate antimicrobial activity, and was the safest for cells even at high concentrations in the cell viability test. It also demonstrated potent anticancer activity and was the most effective COX-2 inhibitor. According to FTIR, the combination of these components was suitable, and the high entrapment efficiency value indicated successful intrathecal loading and controlled release. It remained stable under room storage conditions. Conclusion: Based on the results of previous tests, F22 was a candidate for use in the aforementioned skin problems. Kay words: nanoparticles, herbal oils, ethosome, skin disease and luteolin.