EFFECT OF INTRAVENOUS MAGNESIUM SULFATE IN ACUTE ASTHMA
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Date
2022-01-19
Authors
Mahameed, Abeer
Journal Title
Journal ISSN
Volume Title
Publisher
جامعة النجاح الوطنية
Abstract
Background: Acute asthma exacerbations can lead to admission to the emergency room. When these exacerbations do not respond to standard therapy, guidelines recommend administering a single intravenous bolus dose of magnesium sulfate in addition to standard therapy for the management of patients admitted to the emergency room.
Objective: This study was conducted to evaluate the effectiveness of magnesium sulfate administered intravenously in combination with standard treatment to patients with acute asthma admitted to emergency room settings in a major governmental hospital in Palestine.
Methods: This study was conducted in a quasi-experimental design. Patients in both control and intervention groups were recruited from Al Watani hospital. The patients were recruited during the high season of acute asthma exacerbations. Patients in the control group received standard therapy. Patients in the intervention group received a single intravenous bolus dose of magnesium sulfate in addition to the standard therapy. Demographic and clinical variables of the patients were collected on a data collection sheet. Dyspnea was measured using a modified Borg dyspnea scale.
Results: A total of 65 patients were assigned to control (n = 32) and intervention (n = 33) groups. Patients in both control and intervention groups were similar in terms of demographic and clinical variables before the intervention. There were no significant differences in dyspnea measured before the treatment. Administration of a single intravenous bolus dose of magnesium sulfate in addition to standard therapy was shown to significantly reduce signs of dyspnea as measured in the modified Borg dyspnea scale.
Conclusion: Magnesium sulfate administered intravenously in combination with standard treatment to patients with acute asthma admitted to emergency room settings in Palestine might have improved signs and symptoms of dyspnea compared to standard treatment alone.
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Keywords
Asthma, Exacerbation, Magnesium sulfate, Emergency department