VARIATION IN THE CHEMICAL COMPOSITION AND BIOACTIVE COMPONENTS OF MYRTUS COMMUNIS ESSENTIAL OILS FROM TWO PALESTINIAN REGIONS
| dc.contributor.author | Sumayyah Salim Mohammad Jaber | |
| dc.date.accessioned | 2024-06-09T19:56:49Z | |
| dc.date.available | 2024-06-09T19:56:49Z | |
| dc.date.issued | 2023-02-05 | |
| dc.description.abstract | Abstract Background: One of the reasons why interest in medicinal plants is growing daily is the idea that some plants have the ability to treat a variety of illnesses without having any negative side effects. Myrtus has long been used in many conventional treatments in our region. Objectives: In this study, the chemical profiles of the Myrtus essential oils (EO) that were gathered in Jericho and Jenin will be investigated, along with their antioxidant, anti-amylase, antimicrobial, and anticancer effects. Methodology: Myrtus essential oils (EO) were created via hydro distillation extraction, and the chemical constituents of the EO were characterized qualitatively and quantitatively using GC-MS. Results: Forty one chemicals were found in Jericho EO, with cis-4-Thujanol (27.37%), 1, 8-Cineole (24.32%), Myrtenol (12.97%), Myrtenal (12.46%), and trans-4-Thujanol acetate (9.48%) being the main contributors. There were 37 different chemicals in Jenin EO, with 1,8-cineole (31.55%), linalool (21.65%), Trans-4-thujanol acetate (11.26%), α-pinene(10.22%), Myrtenal(6.78%) and -terpineol(4.35%) being the most prevalent. The antioxidant activity of the EOs was assessed by blocking DPPH free radicals. Jericho and Jenin ethyl acetate extracts outperformed the positive control Trolox, which exhibited an IC50 of 10.25±1.02 g/mL, and demonstrated dose-dependent free radical scavenging capabilities with IC50 values of 8.55±2.31 and 3.60±0.35 g/mL, respectively. Jenin EO has higher antioxidant activity comparison to the EO from Jericho is presumably brought on by larger amounts of oxygenated monoterpenes, such as 1, 8-cineole and -pinene. The most effective α-amylase inhibitory agents were Myrtus EO and extract from Jenin, with IC50 values of 950.48±2.54 and 795.43±1.88µg/mL, respectively, whereas EO and extract from Jericho had no effect. The antitumor activity was tested using the MTS assay. Four cancer cell lines—the human cervical (HeLa), breast (MCF-7), mouse embryo fibroblasts (3T3), and normal hepatic (LX-2) cell line were employed as normal cell lines to test the anti-proliferative activity. Jenin EO has IC50 values between 215.25±1.07 and 597.01±3.11 g/mL, while Jericho EO has values between 644.47±2.89 and 914.54±3.05 g/ml. The antibacterial activity was examined using the microdillution technique. Gram-positive bacteria are more sensitive to both EOs than Gram-negative bacteria. The two EOs have less antifungal efficacy against C. albicans than any other extract under study. Keywords: Bioactive Components; Chemical Composition; Essential Oil; Myrtus; Palestinian. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.11888/19083 | |
| dc.language.iso | en | |
| dc.supervisor | Dr. Nawaf Al-Maharik Dr. Nidal Jaradat | |
| dc.title | VARIATION IN THE CHEMICAL COMPOSITION AND BIOACTIVE COMPONENTS OF MYRTUS COMMUNIS ESSENTIAL OILS FROM TWO PALESTINIAN REGIONS | |
| dc.type | Thesis |