SYNTHESIS, SPECTRAL CHARACTERIZATION, AND BIOLOGICAL SCREENING OF CURCUMIN BASED AZO DYES AND AZO-DYES METAL COMPLEXES
| dc.contributor.author | Ala'a Abed Al-Raheem Janem | |
| dc.date.accessioned | 2024-08-21T08:08:46Z | |
| dc.date.available | 2024-08-21T08:08:46Z | |
| dc.date.issued | 2022-08-13 | |
| dc.description.abstract | Abstract Background: Curcumin is a natural active, vital, and important component derived from Curcuma longa. A significant attention was given to curcumin and its derivatives due to their natural origin, non-toxicity also to their bio functional properties including antioxidant, anti-inflammatory, antitumor, and anti-cancer. Objectives: The main objective of this work is to develop a new set of curcumin derivatives with broad spectrum of bioactivities. Curcumin-based azo compounds and curcumin with alkyl sulfonate moiety were selected to achieve the target objective. Methodology: The method synthesizing curcumin derivatives involves converting some aromatic amines with chlorine, sulfonyl, carboxyl, and ammonium groups to diazonium slat then coupling the diazonium salt with curcumin to produce curcumin-based azo compounds and direct condensation of curcumin alkali with sultone. Results: The newly prepared compounds were characterized by 1H NMR, 13C NMR, FT-IR and melting point. The azo compounds performance as dyes were evaluated. The color change of the azo as a factor pH were studied. The bioactivities of the azo compounds and complexes such as antimicrobial and anticancer wereevaluated (Escherichiacoli, Staphylococcus aureus, klebsiella pneumoniaand Methicillin-resistant Staphylococcus aureus,MCF-7, HEPG2, B16-F110, Colon and HeLa cell lines viability MTT assay in Palestine). Conclusion: A new novel set of curcumin azo dyes and curcumin with alkyl sulfonate moieties were successfully prepared. The antimicrobial and anticancer activities were very promising, which make the compound possible future drugs for treatment of various kinds of cancer. Keywords: Curcumin; Azo; Anticancer; Curcumin Sulfonate; Sultone, Genotoxic. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.11888/19418 | |
| dc.language.iso | en | |
| dc.supervisor | Prof. Othman Hamed | |
| dc.title | SYNTHESIS, SPECTRAL CHARACTERIZATION, AND BIOLOGICAL SCREENING OF CURCUMIN BASED AZO DYES AND AZO-DYES METAL COMPLEXES | |
| dc.type | Thesis |