THE ASSOCIATION OF FCGRIIA AND FCGRIIIA POLYMORPHISMS AND ANTIPLATELETS AUTOANTIBODIES WITH PRIMARY IMMUNE THROMBOCYTOPENIA PATHOGENESIS AMONG PALESTINIAN CHILDREN

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dc.contributor.authorAmer, Khitam
dc.date.accessioned2026-03-18T07:44:33Z
dc.date.available2026-03-18T07:44:33Z
dc.date.issued2026-01-25
dc.description.abstractBackground: Immune thrombocytopenia (ITP) is a common pediatric autoimmune disorder characterized by low platelet counts and bleeding risk. Fc gamma receptors (FcγRs), particularly FCGR2A (131H/R) and FCGR3A (158F/V), mediate immune responses and may influence ITP susceptibility. Gender-related genetic variation has been proposed but remains underexplored. In the current study, we aim to assess the prevalence and clinical relevance of FCGR2A and FCGR3A polymorphisms, including gender-based tendencies, in Palestinian children with ITP. Methods: A multicenter case-control study included 40 proven pediatric ITP patients (20 males, 20 females; mean age (6.76 ± 4.13 years) and 80 age- and sex-matched healthy controls. Genotyping was performed using PCR-RFLP and nested PCR, the antinuclear antibody (ANA) and the anti-double stranded DNA (A- dsDNA) were tested in 32 patient sample using (ELISA). Results: No statistically significant differences in genotype distributions were observed or FCGR3A (FF: 25.0%, FV: 55.0%, VV: 20.0%) (p > 0.05). However, gender specific trends yielded noteworthy observations: FCGR2A-HH was numerically more frequent in male ITP patients (57.4%) than in females (42.8%), while HR was lower in males (48% vs. 52%). Similarly, FCGR3A-VV occurred in 62.5% of males versus 37.5% in females. Furthermore, the combined HR/FV genotype (32.5%) showed a non-significant trend of association with chronic ITP (69.2%), while the VV/HH genotype, although rare (5%), was linked to 50% of refractory presentations. The ANA was positive in 53% of tested samples, and a 3% were positive to both ANA and the A-dsDNA. ANA positive cases (70%) were in patients having the FV and HR genotypes. Conclusion: This exploratory study found no statistically significant association between FCGR2A and FCGR3A polymorphisms and overall ITP susceptibility in the full cohort. However, the observed trends, with gender-based distribution of specific genotypes and the association of combined genotypes with case severity, suggest that these genetic markers may play a role in disease progression. Further investigation in a larger study is warranted to validate these findings.
dc.identifier.urihttps://hdl.handle.net/20.500.11888/20927
dc.language.isoen
dc.publisherAn-Najah National University
dc.supervisorAmer, Johnny
dc.titleTHE ASSOCIATION OF FCGRIIA AND FCGRIIIA POLYMORPHISMS AND ANTIPLATELETS AUTOANTIBODIES WITH PRIMARY IMMUNE THROMBOCYTOPENIA PATHOGENESIS AMONG PALESTINIAN CHILDREN
dc.title.alternativeارتباط تعدد أشكال FCGRIIA وFCGRIIIA والأجسام المضادة الذاتية للصفائح مع التسبب في نقص الصفائح المناعي الأولي لدى الأطفال الفلسطينيين
dc.typeThesis
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