VARIATIONS OF THE CHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF PSIDIUM GUAJAVA ESSENTIAL OIL FROM THREE REGIONS IN PALESTINE

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dc.contributor.authorSaleem, Azeeza
dc.date.accessioned2026-01-05T11:54:53Z
dc.date.available2026-01-05T11:54:53Z
dc.date.issued2025-11-11
dc.description.abstractCurrently, our world is very interested in herbal medicine and people tend to use plants for many disease treatments. Due to the benefits of guava, which is known for its traditional uses, it was chosen as a basic plant in this research. Where the research was carried out on various pharmacological characteristics of guava leaf oil for three different regions in Palestine to study all chemical and medicinal properties of guava oil, to clarify the different composition and what follow that of different pharmacological uses. Guava leaves were picked and collected from three different regions (Qalqilya, Jericho, and Hebron (, using the Hydro-distillation method to extract oils. The oils are used to conduct various tests of their chemical components and laboratory tests to verify the oil’s anti-oxidation and alpha-inhibiting properties of DPPH, alpha-amylase and alpha-glucose lipase as well as against cancer cell lines, according to their constituents that approved by using GC-Ms. As a result, the three types of guava leaf oil have rich chemo diversity while the main components were D-Limonene for Qalqilya and Jericho regions, but beta-Caryophyllene in Hebron region. Qalqilya's oil is better as an anti-obesity and antioxidant because of Benzaldehyde and alpha-Curcumene presenting, and 1,8-cineol and Aromadendrene, respectively. Jericho's oil is the best as antidiabetic according to E-Cinnamaldehyde and verbenone contents, comparing to the less type of three regions was Qalqilya's oil, while Hebron oil is closure to Jericho oil properties. As well as Hebron has more effect on different types of cancer cell lines as Jericho (Hek293t, HepG2, HeLa and MCF-7), Qalqilya oil has an effect on Caco-2 type. These differences were due to geographical locations that make a variation in chemical constituents in these oils. Guava leaves and its components are suggested to be used and targeted for the future researches and medications.
dc.identifier.urihttps://hdl.handle.net/20.500.11888/20738
dc.language.isoen
dc.publisherAn-Najah National University
dc.supervisorJaradat, Nidal
dc.supervisorHawwash, Mohammed
dc.titleVARIATIONS OF THE CHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF PSIDIUM GUAJAVA ESSENTIAL OIL FROM THREE REGIONS IN PALESTINE
dc.title.alternativeتباينات المكونات الكيميائية والأنشطة الدوائية لزيت العطري لنبتة الجوافة من ثلاث مناطق في فلسطين
dc.typeThesis
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