Comparative Pharmacokinetic Study of Single Oral Doses of Ibuprofen in Healthy Volunteers for Palestinian, British and American Pharmaceutical Equivalents in The Local Market

dc.contributor.advisorDr. Ansam Sawalha
dc.contributor.authorAbed-Al-Rahaman Mohammad Jarrar
dc.date.accessioned2017-05-03T09:30:13Z
dc.date.available2017-05-03T09:30:13Z
dc.date.issued2003
dc.description.abstractThis study is conducted so as to test for the existence of actual or potential bioequivalence problems belonging to pharmaceutical equivalents of ibuprofen drug specifically the Palestinian local quality, British (Nurofen ) and American (Advil ) formulations available in the local market.To carry out this study three samples each of 24 healthy volunteers of both genders (12 males and 12 females) with the following average characteristics: age, weight, height and body mass index 20.667(year), 65.292(kg), 1.6929(m) and 22.750(kg/mยฒ) respectively were admitted to the central laboratory of An-Najah National university and a single oral dose of 400 mg of each of the formulations was administered. Three blood samples were withdrawn to measure the drugs concentrations at three periods of time- (0.5hr, 1 hr and 1.5hr following administration). The analysis of blood plasma samples after cleaning them was carried out by utilizing the HPLC/UV. The concentration of ibuprofen in each sample was calculated and upon analyzing the results statistically, it was verified with a high degree of validation that there is a significant bio equivalence problem regarding the local brand relative to the other pharmaceutical equivalents and the difference between Nurofen and Advil was of no significant value.en
dc.description.abstractูŠู‡ุฏู ู‡ุฐุง ุงู„ุจุญุซ ุฅู„ู‰ ู…ู‚ุงุฑู†ุฉ ุงู„ุชูˆุงูุฑ ุงู„ุญูŠูˆูŠ ู„ุซู„ุงุซ ุชุฑูƒูŠุจุงุช ุนู„ุงุฌูŠุฉ ู…ุชูƒุงูุฆุฉ ู„ุฏูˆุงุก ุงู„ุฃูŠุจูˆุจุฑูˆููŠู† ุฅุญุฏุงู‡ุง ุฐูˆ ุตู†ุงุนุฉ ู…ุญู„ูŠุฉ ูˆุงู„ุงุฎุฑูŠู† ุตู†ุงุนุฉ ุฃุฌู†ุจูŠุฉ ูˆู‡ู…ุง ุงู„ู†ูŠูˆุฑูˆููŠู† ูˆุงู„ุฃุฏููŠู„. ู…ู† ุฃุฌู„ ุงู„ู‚ูŠุงู… ุจู‡ุฐู‡ ุงู„ุฏุฑุงุณุฉ ูƒุงู† ู„ุง ุจุฏ ู…ู† ุฃุฎุฐ ุซู„ุงุซ ุนูŠู†ุงุช ู…ู† ุงู„ุฏู… ุนู„ู‰ ุงู„ุฃู‚ู„ ูˆุนู„ู‰ ุซู„ุงุซ ูุชุฑุงุช (ู†ุตู ุณุงุนุฉุŒ ุณุงุนุฉ ูˆุณุงุนุฉ ูˆู†ุตู) ูˆุฐู„ูƒ ุจุนุฏ ุฃู† ูŠุฃุฎุฐ ูƒู„ ุดุฎุต ู…ู† ูƒู„ ู…ุฌู…ูˆุนุฉ (ุซู„ุงุซ ู…ุฌู…ูˆุนุงุช ูˆูƒู„ ู…ุฌู…ูˆุนุฉ ุชุถู… 24 ู…ุชุจุฑุน ู…ู† ุทู„ุจุฉ ุงู„ุฌุงู…ุนุฉ ู…ู† ูƒู„ุง ุงู„ุฌู†ุณูŠู†) ู‚ุฑุตุง ู…ู† ุฃุญุฏ ุงู„ุฃุฏูˆูŠุฉ. ุชู…ุช ุนู…ู„ูŠุฉ ุฃุฎุฐ ุงู„ุนูŠู†ุงุช ููŠ ุงู„ู…ุฎุชุจุฑุงุช ุงู„ู…ุฑูƒุฒูŠุฉ ู„ู„ุฌุงู…ุนุฉุŒ ูƒู…ุง ุชู…ุช ุนู…ู„ูŠุฉ ุชุญู„ูŠู„ ุงู„ุนูŠู†ุงุช ู…ู† ุฃุฌู„ ู‚ูŠุงุณ ุชุฑูƒูŠุฒ ุงู„ุฃูŠุจูˆุจุฑูˆููŠู† ููŠ ูƒู„ ุนูŠู†ุฉ ูˆุฐู„ูƒ ุจูˆุงุณุทุฉ ุฌู‡ุงุฒ (HPLC/U.V). ุจุนุฏ ุฃู† ุชู…ุช ุนู…ู„ูŠุฉ ุงู„ุชุญู„ูŠู„ ุงู„ุงุญุตุงุฆูŠ ู„ู„ู†ุชุงุฆุฌ ูู‚ุฏ ุชุจูŠู† ุฃู† ู‡ู†ุงูƒ ูุฑู‚ุง ุฐุง ุฏู„ุงู„ุฉ ุฅุญุตุงุฆูŠุฉ ููŠ ู…ุนุฏู„ ุงู„ุงู…ุชุตุงุต ุจูŠู† ุงู„ุฃุฏูˆูŠุฉ ุงู„ุซู„ุงุซุฉ ุญูŠุซ ุฃู†ู‡ ูƒุงู† ุงู„ุงู‚ู„ ููŠ ุญุงู„ุฉ ุงู„ู†ูˆุนูŠุฉ ุงู„ู…ุญู„ูŠุฉ ุจูŠู†ู…ุง ูƒุงู† ู…ุชุณุงูˆูŠุง ููŠ ุญุงู„ุฉ ุงู„ู†ูŠูˆุฑูˆููŠู† ูˆุงู„ุฃุฏููŠู„ุŒ ูƒู…ุง ุฃู† ุชุฑูƒูŠุฒ ุงู„ุฃูŠุจูˆุจุฑูˆููŠู† ููŠ ุงู„ุฏู… ู„ู„ู†ูˆุนูŠุฉ ุงู„ู…ุญู„ูŠุฉ ูƒุงู† ุฏูˆู† ุงู„ู…ุณุชูˆู‰ ุงู„ุนู„ุงุฌูŠ ุงู„ู…ุทู„ูˆุจ. ุงุฑุฌูˆ ุฃู† ุชูƒูˆู† ู‡ุฐู‡ ุงู„ุฏุฑุงุณุฉ ู‚ุฏ ุณุงู‡ู…ุช ููŠ ู…ุฌุงู„ ุงู„ุฑู‚ุงุจุฉ ุงู„ุฏูˆุงุฆูŠุฉ ูˆุฐู„ูƒ ู…ู† ุงุฌู„ ุงู„ู…ุญุงูุธุฉ ุนู„ู‰ ุตุญุฉ ู…ุฌุชู…ุนู†ุง.ar
dc.identifier.urihttps://hdl.handle.net/20.500.11888/7670
dc.titleComparative Pharmacokinetic Study of Single Oral Doses of Ibuprofen in Healthy Volunteers for Palestinian, British and American Pharmaceutical Equivalents in The Local Marketen
dc.titleู…ู‚ุงุฑู†ุฉ ุงู„ุชูˆุงูุฑ ุงู„ุญูŠูˆูŠ ู„ุซู„ุงุซ ุชุฑูƒูŠุจุงุช ุนู„ุงุฌูŠุฉ ู…ุชูƒุงูุฆุฉ ู„ุฏูˆุงุก ุงู„ุงูŠุจูˆุจุฑูˆููŠู† (ู†ูˆุนูŠุฉ ู…ุญู„ูŠุฉ,ู†ูŠูˆุฑูˆููŠู† ุงู†ุฌู„ูŠุฒูŠ ูˆุงู„ุงุฏููŠู„ ุงู„ุงู…ุฑูŠูƒูŠ) ููŠ ุงู„ุณูˆู‚ ุงู„ู…ุญู„ูŠar
dc.typeThesis
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