SUCROSE BASED CISPLATIN ANALOGS: SYNTHESIS AND ANTICANCER ACTIVITY
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Date
2023-05-09
Authors
Mai Salam Mahmoud Badran
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Abstract
Sucrose chemistry has received a lot of attention since 1960s. Currently, over three hundred well identified sucrose derivatives have been reported in the literature as it is safe, abundant, and available at low cost. This work is planned on creating a drug for cancer with greater effectiveness and low toxicity based on sugar molecules.
The main goal of this study is to develop a unique, naturally derived cisplatin analogue. That can be used as a replacement for cisplatin and free of the side effect of the cisplatin.
To achieve the goal of the study two sucrose-based cisplatin complexes were synthesized from sugar. The synthesis was performed in a three-step process. The first step involved adding acetoacetate functionality to the sucrose, converting the acetoacetate functionality of Schiff base by reacting it with valine and 2,3-diaminopyrdien. The last step involved making the sucrose based cisplatin analog by complexing the potassium tetrachloro palatinate (K2PtCl4).
The structures of the prepared compound were identified by FT-IR and some by NMR spectroscopy. The cisplatin complexes showed a clear activity against Hela cancer cells. The inhibition reached about 67% and they showed mild effect on normal cells as the effect reached about 29%. The Schiff bases showed lower effect on Hella cancer cells.
The study concluded that sucrose based cis-platin analogues were successfully synthesized and their anticancer activity were evaluated. They showed promising results and Hela cancer cells. Still more work needs to done on structure elucidation and the activities of the cisplatin analogues against other cancer cells.
Keywords: Cancer, Schiff bases, Cisplatin analogues, Potassium tetrachloro platinate, Sucrose, Amino acids.