METABOlOMICS AND ANTI-MICROBIAL ACTIVITY OF MORINGA OLEIFERA
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Date
2021-07-27
Authors
Ammar, Mohammed
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Abstract
The World Health Organization's Global Antimicrobial Surveillance System report tracked the occurrence of bacterial infections with antibiotic resistance in half a million people around the world. Moreover, Multi-resistant strains are becoming more common and dispersed, posing a serious threat to public health. As a result of this situation, alternative strategies were investigated, including herbal extracts and plant-derived compounds. Antibiotic resistance is defined as a drug's inability to kill a microbe that it was previously used to inhibit or kill. Antimicrobial resistance is widespread around the world, posing a threat to the ability to manage common infectious diseases, resulting in increased mortality and morbidity. Medicinal plants have been used to treat common infectious diseases since ancient times. Also, it can be considered a safe, and cheap source for microbial treatment. Consequently, the efficacy and efficiency of medicinal plants in the antimicrobial domain that encourages researchers to study their compositions and investigate them as a natural way to control and inhibit bacteria activity. An example of herbs that have antimicrobial activity, which has been studied is Guava (Psidium guajava), Sage (Salvia officinalis), Rhamnus (Ziziphusspina Christi), Mulberry (Morusalba L.) which they show good antimicrobial activity.
Ben oil is an ancient medicine obtained by the seeds of Moringa oleifera Lam. Plant. It has been used for a variety of purposes. It has also been the subject of considerable research due to its multiple applications and well-known bactericidal properties. In addition, it contains a substance called pterygospermin, which has antibacterial and fungicidal properties. M. oleifera extracts from seeds, leaves, root, and seed oil extracted using various solvents have been shown to inhibit the growth of gram-positive and gram-negative bacteria in general. Furthermore, M. oleifera parts have been reported to be a rich source of phytochemicals such as flavonoids, phenolic, and alkaloid compounds, as well as bioactive peptide and polysaccharide compounds which can be used as antimicrobials