(2011-06-01) Ahmad I. Husein; Mohammed S. Ali-Shtayeh; Nidal A. Zatar; Waheed Jondi
Ethanolic extracts of six plants (Arum palaestinum, Urtica pilulifera, Coridothymus capitatus, Majorana syriaca, Teucrium creticum, Teucrium polium), used in traditional medicine in Palestine were tested for their antioxidant and anticancer activities. They showed different ranges of antioxidant activity due to DPPH and β-Carotene-linoleic acid assays. The extracts were also tested for their ability to inhibit the proliferation of breast cancer cells (MCF-7) using the MTT reduction assay. The extract of U. pilulifera revealed the highest antioxidant due to β-Carotene-linoleic acid assay and showed the highest cytotoxicity against breast cancer.
New heteroring-substituted thiophene-2-carbohydrazides incorporating pyrrole, thiophene,
and pyridine moieties have been synthesized, characterized, and screened for possible
antimicrobial activity. Some of the synthesized compounds exhibited promising antibacterial
activities, but rather modest antifungal activity.