Medical and Health Sciences

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Browsing Medical and Health Sciences by Author "Bara'a Khaleel Rawajbeh"

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    ENVIRONMENTAL AND GENETIC RISK FACTORS AMONG TYPE 1 DIABETES MELLITUS / CASE CONTROL STUDY IN NABLUS CITY
    (2023-10-03) Bara'a Khaleel Rawajbeh
    Abstract Type 1 diabetes is a result of an autoimmune reaction in which the body immune system attack himself the exact risk factors that enhance this mechanism are not as clear as for type 2. In this study, a questionnaire for risk factors (environmental and genetic factors) for type 1 diabetes mellitus at maternal and child level. The study is aiming for identifying the risk factors (environmental & genetic) at maternal and patient level associated with type 1 diabetes mellitus in Nablus city West Bank, Palestine. A case control study design was adopted to find the risk factors associated with type 1 diabetes occurrence 68 cases and 50 control filled a questionnaire that was developed by the researcher, then the data was analyzed by SPSS. A total of 118 participants included in the study: 68 cases (57.6%), 50 controls (42.4%), mean age in cases 8.8703 ±5.2053, mean age of controls 8.5600±5.83938. 53.4% males and 46.6% females. The comparison between case and control groups showed significant association with multiple risk factors. BMI pre pregnancy (p 0.009), hypertension during pregnancy (p 0.077, OR 5.623, 95%CI 0.8294 – 1.4206), exposure to hair salon chemicals (p 0.033, OR 4.632, 95%CI 0.9269 – 1.3808), passive smoker (p 0.002, OR 3.458, 95%CI 1.1415 – 1.3868), consumption of soft drinks (p 0.051, OR 2.217, 95%CI 1.1516 – 1.4484), and family history of T1DM (p 0.000, OR 42.690, 95% CI1.4095 – 1.6109). T1DM is associated with genetic and environmental risk factors. Recommendation for further studies about the result founded in this study, with more sample size, and more details Keywords: Diabetes and risk factors; T1DM.