Influence of Corchorus Olitorius (Molokhia) Soup on the In Vivo Absorption of Ciprofloxacin from Immediate Release Tablet in Rabbits

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dc.contributor.authorAnwar Alheen
dc.contributor.authorAsma Radwan
dc.contributor.authorJosephean Elaraj1
dc.contributor.authorMalak Jada'a
dc.contributor.authorMohamad Abdaldaym3
dc.contributor.authorNaser Shraim
dc.contributor.authorNidal Zatar
dc.contributor.authorYasmeen Khanfar
dc.date.accessioned2017-04-20T07:22:04Z
dc.date.available2017-04-20T07:22:04Z
dc.date.issued2016
dc.description.abstractThis study was undertaken to evaluate the effect of Corchorus Olitorius (Molokhia) soup on the oral absorption of ciprofloxacin from solid dosage forms in rabbits. A single dose of ciprofloxacin tablet (125 mg) was administered to rabbits in a fasted state or with Molokhia soup. Plasma ciprofloxacin concentrations were measured by high-performance liquid chromatography. The results demonstrated a profound effect of Molokhia soup on the bioavailability of ciprofloxacin compared to the fasted state. The intake of Molokhia soup reduced the rate and extent of ciprofloxacin oral bioavailability. The geometric mean (Cmax and AUC) values of ciprofloxacin were significantly lower under fed compared to the fasted states. Administration of ciprofloxacin with Molokhia soup was associated with a delay in the time to reach peak concentration (Tmax) by about half hour. Therefore, co-administration of Molokhia soup with ciprofloxacin may have a potential negative effect on the release and oral absorption of Ciprofloxacin from tablets, This may result in serious decrease in the efficacy of this antibiotic and potential bacterial resistance.en
dc.identifier2413-8568
dc.identifier.urihttps://hdl.handle.net/20.500.11888/3147
dc.titleInfluence of Corchorus Olitorius (Molokhia) Soup on the In Vivo Absorption of Ciprofloxacin from Immediate Release Tablet in Rabbitsen
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Palestinian Medical and Pharmaceutical Journal (PMPJ)