EFFECT OF DAILY ADMINISTRATION OF MICROENCAPSULATED LIMOSILACTOBACILLUS REUTERI DSM 17938 ON THE INTESTINAL MICROBIOTA AND METABOLIC ALTERATION INDUCED BY HIGH FAT FRUCTOSE DIET IN ADULT RATS
| dc.contributor.author | Abuqwider, Jumana | |
| dc.date.accessioned | 2022-09-19T05:56:01Z | |
| dc.date.available | 2022-09-19T05:56:01Z | |
| dc.date.issued | 2021-07-26 | |
| dc.description.abstract | Aims: To investigate the intestinal microbiota and metabolic alteration of 8-week oral supplementation with microencapsulated Lactobacillus reuteri DSM 17938 induced by high fat fructose diet in adult rats. Materials and methods: In animal experiment, Male Wistar rats of 90 days were fed a control diet or a high fat - high fructose diet for 8 weeks, promoting signs of obesity and metabolic syndrome. Rats either fed a Control diet or HFF diet were divided into three groups. The first one, the control group (C) with the low-fat diet, the second, with the administration of the L. reuteri inside the microcapsule (CRM), while the last, were received simply L. reuteri (CR). In the same way the rats treated with a high fat - high fructose (HFF) diet were divided in three groups: one with the HFF (T), second group was administrated the L. reuteri inside the microcapsule (TRM), and the third group, was administrated by the HFF diet and the L. reuteri (TR). The research investigates the effect of supplementation on glucose homeostasis, body composition, energy balance, hepatic steatosis and fecal microbiota composition. Results: Supplementation with microencapsulated L. reuteri DSM 17938 for 8 weeks did not affect significantly body composition and energy balance but affect significantly the plasma glucose and insulin resistance, liver steatosis, and microbiota composition. Rats who received the microencapsulated L. reuteri exhibited decreases in plasma glucose compared with control. In addition, microencapsulated L. reuteri supplementation significantly suppressed liver enzymes (AST, ALT) and hepatic steatosis, also increase the abundance of Akkermansia muciniphila which improves host metabolic parameters. Conclusions: Intake of microencapsulated L. reuteri DSM 17938 for 8 weeks with diet induced obesity did not affect body composition and energy balance; however, it improved plasma glucose, insulin sensitivity, fatty liver | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.11888/17157 | |
| dc.language.iso | en | en_US |
| dc.publisher | جامعة النجاح الوطنية | en_US |
| dc.supervisor | Dr. Mohammad Tamimi Prof. Gianluigi Mauriello | en_US |
| dc.title | EFFECT OF DAILY ADMINISTRATION OF MICROENCAPSULATED LIMOSILACTOBACILLUS REUTERI DSM 17938 ON THE INTESTINAL MICROBIOTA AND METABOLIC ALTERATION INDUCED BY HIGH FAT FRUCTOSE DIET IN ADULT RATS | en_US |
| dc.title.alternative | تأثير التزويد اليومي لليموسيلاكتوباسلس ريوتيري DSM 17938 المتحوصلة على ميكروبيوتا الامعاء والتغيرات الأيضية محفز بنظام غذائي عالي بالدهون والفركتوز في الجرذان البالغة | en_US |
| dc.type | Thesis | en_US |