EPIDEMIOLOGY AND ANTIMICROBIAL SUSCEPTIBILITY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES: A RETROSPECTIVE STUDY AT A TERTIARY CARE HOSPITAL IN PALESTINE BETWEEN 2020-2021
| dc.contributor.author | Hala Zidan Masri | |
| dc.date.accessioned | 2024-05-22T06:21:30Z | |
| dc.date.available | 2024-05-22T06:21:30Z | |
| dc.date.issued | 2023-06-14 | |
| dc.description.abstract | Increased rates of resistance of Staphylococcus aureus (S. aureus) to different classes of antibiotics, makes the researchers think about studying the antimicrobial profile of it, and other risk factors that may be associated with infection. The goals of our study are to determine the prevalence of methicillin-resistant S. aureus (MRSA) among Palestinian patients, and to identify risk factors, susceptibility patterns, and to determine the most suitable antibiotics to be used empirically. Data of positive S. aureus cultures from patients’ specimens during the time period between January 2020 and December 2021 was collected from An-Najah National University Hospital, Nablus-Palestine, classified to methicillin-sensitive S. aureus (MSSA) or MRSA by using Vitek 2 system which is available in the hospital. Each isolate was tested for susceptibility to each oxacillin, cefuroxime, amoxicillin, piperacillin-tazobactam clindamycin, erythromycin, gentamycin, levofloxacin, linezolid, moxifloxacin, ciprofloxacin, quinopristin/dalfopristin, rifampicin, tetracycline, tigecycline, trimethoprim-sulfamethoxazole (TMP-SMX), and vancomycin by Vitek2 system. Other information related to patients and other comorbidities were collected from the hospital information system. 126 (49.6%) of 254 patients with S. aureus were infected with MRSA, with no significant association with various age groups and gender. Prevalence of MRSA was highest in pediatric unit followed by emergency room, 61.1% and 59.6% respectively, followed by surgical unit with MRSA prevalence of 52.7%. There is a significant difference in MRSA and MSSA distribution in the kidney unit (p-value = 0.009). Lung diseases are the co-morbidities which are associated with MRSA. Skin and soft tissues, and pus/wound specimen are associated with MRSA infection. All isolated were still susceptible to vancomycin. The prevalence of MRSA seemed to be similar to other Asian countries. Vancomycin is the most suitable option to be used empirically for serious MRSA infections. Keywords: Methicillin-resistant Staphylococcus aureus, resistance, risk factors, susceptibility pattern. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.11888/18749 | |
| dc.language.iso | en | |
| dc.supervisor | Dr. Adham Abu Taha | |
| dc.title | EPIDEMIOLOGY AND ANTIMICROBIAL SUSCEPTIBILITY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES: A RETROSPECTIVE STUDY AT A TERTIARY CARE HOSPITAL IN PALESTINE BETWEEN 2020-2021 | |
| dc.type | Thesis |