Synthesis of a New Series of Heterocyclic Scaffolds for Medicinal Purposes

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dc.contributor.authorR. Arafat
dc.contributor.authorM.S. Ali-Shtayeh
dc.contributor.authorT. Al-Tel
dc.contributor.authorW. Voelter
dc.contributor.authorA. Barakat
dc.contributor.authorH.S. Hilal
dc.date.accessioned2017-05-03T09:36:45Z
dc.date.available2017-05-03T09:36:45Z
dc.date.issued2011-06-01
dc.description.abstract<p>A new series of substituted 8-fluro-4H-pyrimido[2,1-b] [1,3]benzothiazole-4-ones, substituted 7-methyl-4H-isoxazolo[2,3-a]pyrimidin-4-ones, and substituted 2-methyl-5,6,7,8-tetrahydro- 9H-isoxazolo[2,3-a]pyridopyrimidin-9-ones, compounds I–VII, have been prepared for possible use in medicinal application. The preparation followed condensation of β-keto esters with 2- aminopyridine derivatives, in the presence of polyphosphoric acid. The same technique has also been used to prepare diazepine compounds, VIII–X, by condensation of a γ-keto ester with 2-aminopyridine derivatives. Details of synthetic procedures are shown. The new compounds have been characterized by elemental analysis, GC–MS, FT-IR and NMR spectrometry. Bioactivity of these compounds has been investigated.</p>en
dc.description.abstract<p>A new series of substituted 8-fluro-4H-pyrimido[2,1-b] [1,3]benzothiazole-4-ones, substituted 7-methyl-4H-isoxazolo[2,3-a]pyrimidin-4-ones, and substituted 2-methyl-5,6,7,8-tetrahydro- 9H-isoxazolo[2,3-a]pyridopyrimidin-9-ones, compounds I–VII, have been prepared for possible use in medicinal application. The preparation followed condensation of β-keto esters with 2- aminopyridine derivatives, in the presence of polyphosphoric acid. The same technique has also been used to prepare diazepine compounds, VIII–X, by condensation of a γ-keto ester with 2-aminopyridine derivatives. Details of synthetic procedures are shown. The new compounds have been characterized by elemental analysis, GC–MS, FT-IR and NMR spectrometry. Bioactivity of these compounds has been investigated.</p>ar
dc.identifier.urihttps://hdl.handle.net/20.500.11888/9521
dc.titleSynthesis of a New Series of Heterocyclic Scaffolds for Medicinal Purposesen
dc.titleSynthesis of a New Series of Heterocyclic Scaffolds for Medicinal Purposesar
dc.typeOther
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The Fifth Palestinian International Chemistry Conference