Evaluation of Food Effect on the Absorption of Clarithromycin using Physiological Modeling

dc.contributor.advisor	Dr. Asma Radwan
dc.contributor.author	Sa'ed Abu shamma
dc.contributor.author	Israa Khalid Ibrahim
dc.contributor.author	Omar Ghanam
dc.date.accessioned	2020-08-10T09:25:04Z
dc.date.available	2020-08-10T09:25:04Z
dc.date.issued	2016-05-30
dc.description.abstract	Background: Food may have an impact on the oral absorption of ibuprofen from gastrointestinal tract (GI) by affecting its dissolution rate or by inducing physiological changes in the GI tract. Aim : is to evaluate the effect of FDA standard food on the in vitro release and disintegration of ibuprofen from immediate release tablet. Method: In vitro disintegration and dissolution of ibuprofen 400 mg immediate release (IR) tablet in compendial media with/without the addition of homogenized FDA meal were determined. Results: Prolonged tablet disintegration time and slower dissolution rateswere shown in the presence of FDA meal (fed state) compared to the fast state (compendial media) Conclusion: The intake of FDA meal with ibuprofen may help in reducing the side effects of ibuprofen however, it may decrease the therapeutic effect and the bioavailability of the drug	en_US
dc.identifier.uri	https://hdl.handle.net/20.500.11888/15219
dc.language.iso	en	en_US
dc.title	Evaluation of Food Effect on the Absorption of Clarithromycin using Physiological Modeling	en_US
dc.type	Graduation Project	en_US

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