Size Selective Synthesis of Sulfur Nanoparticles and their Anti Cancer Activity

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Al-Ali, Anas
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Sulfur is an important element with many practical applications when present as nanoparticles. Nanosize sulfur particles also have many important applications like in pharmaceuticals, medicine, synthesis of nano-composites for lithium batteries, modification of carbon nano tubes [1]. Different methods were used for nano-sized particle synthesis; among those, chemical precipitation, electrochemical method, micro emulsion technique, composing of oil, surfactant, co-surfactant, aqueous phases with the specific compositions and ultrasonic treatment of sulfur-cystine solution [2]. In this work sulfur nanoparticles (S NPs) were prepared by a quick precipitation method with and without using a surfactant to stabilize the formed S NPs. The synthesized S NPs were characterized by XRD, SEM and TEM in order to confirm their sizes and structures. Application of nanotechnology is suggested for diagnosis and treatment of cancer [3]. The anticancer activity of the prepared S NPs has been tested on various types of cancer cell clones including leukemia, kidney and colon cancers. The desired S NPs revealed a high promising activity and selectivity toward killing kidney cancer . References: [1] P. Santiago, E. Carvajal, D.M Mendoza, L. Rendon. (2006) Synthesis and Structural Characterization of Sulfur Nanowires. Microsc. Microanal., 12,690. [2] M. Suleiman, A. Al Ali, A. Hussein, B. Hammouti, T.Hadda, I.Warad. (2013) Sulfur Nanoparticles: Synthesis, Characterizations and their Applications. J. Mater. Environ. Sci., 4, 1029-1033. [3] F.Alexis, E.Pridgen, L.Molnar, O.Farokhzad. (2008) Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharmacol, 5, 05–15.
Sulfur Nanoparticles (SNPs)