Antibacterial activity of Rosmarinus officinalis L., alone and in combination with cefuroxime, against methicillin-resistant Staphylococcus aureus
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Date
2010-09-26
Authors
Nasser Jarrar
Awni Abu-Hijleh
Kamel Adwan
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Abstract
<p>Objective: To determine the antimicrobial activity of rosemary (Rosmarinus officinalis L.)<br />
and to investigate the synergistic effects of this extract combined with ceforuxime against<br />
methicillin-resistant Staphylococcus aureus (MRSA). Methods: The inhibitory and<br />
bactericidal activities of rosemary ethanol extract, alone and in combination with cefuroxime,were studied. Results: The minimum inhibitory concentrations (MICs) of the ethanol extract of rosemary were in the range of 0.39 to 3.13 mg/ml. The minimum bactericidal<br />
concentrations (MBCs) were usually equal to or double that MICs. The antimicrobial activity<br />
of combinations of the ethanol extract of rosemary and cefuroxime indicated their synergistic<br />
effects against all MRSAs. Conclusion: The present work clearly demonstrates that rosemary<br />
has a key role in the elevation of susceptibility to β -lactams.</p>
<p>Objective: To determine the antimicrobial activity of rosemary (Rosmarinus officinalis L.)<br /> and to investigate the synergistic effects of this extract combined with ceforuxime against<br /> methicillin-resistant Staphylococcus aureus (MRSA). Methods: The inhibitory and<br /> bactericidal activities of rosemary ethanol extract, alone and in combination with cefuroxime,were studied. Results: The minimum inhibitory concentrations (MICs) of the ethanol extract of rosemary were in the range of 0.39 to 3.13 mg/ml. The minimum bactericidal<br /> concentrations (MBCs) were usually equal to or double that MICs. The antimicrobial activity<br /> of combinations of the ethanol extract of rosemary and cefuroxime indicated their synergistic<br /> effects against all MRSAs. Conclusion: The present work clearly demonstrates that rosemary<br /> has a key role in the elevation of susceptibility to β -lactams.</p>
<p>Objective: To determine the antimicrobial activity of rosemary (Rosmarinus officinalis L.)<br /> and to investigate the synergistic effects of this extract combined with ceforuxime against<br /> methicillin-resistant Staphylococcus aureus (MRSA). Methods: The inhibitory and<br /> bactericidal activities of rosemary ethanol extract, alone and in combination with cefuroxime,were studied. Results: The minimum inhibitory concentrations (MICs) of the ethanol extract of rosemary were in the range of 0.39 to 3.13 mg/ml. The minimum bactericidal<br /> concentrations (MBCs) were usually equal to or double that MICs. The antimicrobial activity<br /> of combinations of the ethanol extract of rosemary and cefuroxime indicated their synergistic<br /> effects against all MRSAs. Conclusion: The present work clearly demonstrates that rosemary<br /> has a key role in the elevation of susceptibility to β -lactams.</p>