Uropathogens and antibiotic resistance in the community and hospital-acquired urinary tract infected adults at a tertiary care hospital in Palestine

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dc.contributor.authorAya Herbawi
dc.date.accessioned2021-08-29T11:42:00Z
dc.date.available2021-08-29T11:42:00Z
dc.date.issued2021-07-20
dc.description.abstractBackground: Urinary tract infection (UTI) is the most common infection in the community. The causative agents and antibiotic resistance differ between community-acquired and hospital-acquired urinary tract infections. Objectives: This study aimed at identifying the etiologic agents in both community-acquired and hospital-acquired urinary tract infections and to determine the antibiotic resistance pattern of the most frequent organisms. Methods: This is a retrospective cross sectional study of positive urine cultures of adult patients attending An-Najah National University Hospital (NNUH) between the period of Jan 2019 and Dec 2020. Each patient’s age, sex, and urine culture results were obtained from the microbiology lab of NNUH. Microbiology reports included the isolated microorganisms and their antibiotic susceptibility patterns. Results: A total of 798 patients were included in the study, of which 472 (59.1%) were female. Escherichia coli was the most common uropathogen, accounting for 37.8% of the CAUTI and 25.1% of the HAUTI. In CAUTI, E. coli was followed by E. faecalis (16.4%), Klebsiella (13.7%), E. faecium (6.5%), and Streptococcus agalactia (4.9%). Among HAUTIs, the second most common was Klebsiella (21.4%) followed by E. faecium (19.3%), E. faecalis (13.4%), and Pseudomonas aeruginosa (7%). The rates of ESBL-producing strains of E. coli were similar between CAUTI (54.1%) and HAUTI (53.2%). E. coli from CAUTI and HAUTI was sensitive to carbapenems, amikacin, and nitrofurantoin. The antibiotics with the highest resistance rates were ampicillin, cefuroxime, cotrimoxazole, and ciprofloxacin. Resistance rates were higher in HAUTI than in CAUTI. Conclusions: The distribution of uropathogenic species was different between CAUTI and HAUTI. Higher resistance rates were observed in the HAUTIen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11888/16018
dc.language.isoenen_US
dc.titleUropathogens and antibiotic resistance in the community and hospital-acquired urinary tract infected adults at a tertiary care hospital in Palestineen_US
dc.typeGraduation projecten_US
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