Determination of Haloperidol Hydrochloride in Ampoulesandin Urine Samples Using a New Potentiometric Carbon Paste Electrode
Date
2015-04-21
Authors
Abu Shawish, Hazem M.
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Abstract
A novel approach for the determination of haloperidol hydrochloride (HDCl) in
pharmaceutical formulations and in urine samples is presented. New carbon paste
electrode for HDCl based on Haloperidol-phosphomolybdateas (an ion-exchanger)
dissolved in plasticizer DBP and their potentiometric characteristics were
discussed. The electrode exhibited a good Nernstian slope of 56.9±0.3 mV/decade
with a linear concentration range from 3.5 × 10-6 - 1.0 × 10-2 M for the haloperidol
ion. The limit of detection was 1.6 × 10-6 M. It had response time of 5-8 sec,
useable in pH range of 6.2–8.6 and temperature of 20–60o C. The electrode shows
clear discrimination of haloperidol hydrochloride from several inorganic ions,
sugars and some common drug excipients. The sensor was applied for
determination of haloperidol hydrochloride in urine and in pharmaceutical
formulations using potentiometric determination, standard addition and the
calibration curve methods. The results are satisfactory with excellent percentage
recovery comparable or better than those obtained by other routine methods.
Description
Keywords
potentiometric , ephedrine hydrochloride , coated wire electrode , ionselective electrode