Palestinian Medical and Pharmaceutical Journal (PMPJ)

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https://hdl.handle.net/20.500.11888/814

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Browsing Palestinian Medical and Pharmaceutical Journal (PMPJ) by Author "Asma Radwan"

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    Community Pharmacists’ Knowledge towards the Proper Dosing Instructions and Interactions of Alendronate Therapy
    (2017) Asma Radwan; Hadeel Jadallah; Haneen Zaid; Josephean Elaraj1; Masa Nour; Mohammad Ya’aqba; Raghad Salamah
    Alendronate is one of the most commonly prescribed drugs for the treatment of osteoporosis and other diseases characterized by increased bone resorption. Poor compliance increases the fracture risks, and ultimately treatment failure. This study aims to evaluate Palestinian pharmacist’s knowledge of the proper administration instructions, interactions and side effects of Alendronate as this significantly affect the medical effectiveness and the development of adverse effects. Self- administered questionnaires were completed by 230 pharmacists working in community pharmacies in the northern area of the West Bank. Data were collected using a validated questionnaire consisting of 4 sections and analyzed by descriptive statistics. A scoring scheme was developed to estimate the knowledge scores of participants for the various parameters. The obtained knowledge scores were correlated with the socio-demographics characteristics of the pharmacist's. The median knowledge score of the pharmacists regarding the proper use of Alendronate was moderate i.e., 6 out of a possible maximum score of 9. The knowledge score of Alendronate interactions with food and other medications was 10.5 out of a possible maximum of 14 which is considered as a moderate score, whereas, that for side effects was 4 (0-8). Factors affecting the knowledge towards Alendronate dosing instructions, side effects, and interactions were gender, employment status, years of experience and work place. In conclusion, Palestinian pharmacists have intermediate knowledge about the proper use, drug-food interactions and side effects of Alendronate. Knowledge gaps were identified by this study. Therefore, improving pharmacist's knowledge is of great importance to achieve better efficacy and safety from the treatment.
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    Influence of Corchorus Olitorius (Molokhia) Soup on the In Vivo Absorption of Ciprofloxacin from Immediate Release Tablet in Rabbits
    (2016) Anwar Alheen; Asma Radwan; Josephean Elaraj1; Malak Jada'a; Mohamad Abdaldaym3; Naser Shraim; Nidal Zatar; Yasmeen Khanfar
    This study was undertaken to evaluate the effect of Corchorus Olitorius (Molokhia) soup on the oral absorption of ciprofloxacin from solid dosage forms in rabbits. A single dose of ciprofloxacin tablet (125 mg) was administered to rabbits in a fasted state or with Molokhia soup. Plasma ciprofloxacin concentrations were measured by high-performance liquid chromatography. The results demonstrated a profound effect of Molokhia soup on the bioavailability of ciprofloxacin compared to the fasted state. The intake of Molokhia soup reduced the rate and extent of ciprofloxacin oral bioavailability. The geometric mean (Cmax and AUC) values of ciprofloxacin were significantly lower under fed compared to the fasted states. Administration of ciprofloxacin with Molokhia soup was associated with a delay in the time to reach peak concentration (Tmax) by about half hour. Therefore, co-administration of Molokhia soup with ciprofloxacin may have a potential negative effect on the release and oral absorption of Ciprofloxacin from tablets, This may result in serious decrease in the efficacy of this antibiotic and potential bacterial resistance.