Faculty of Medicine and Health Sciences
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- ItemAdherence to Stress Ulcer Prophylaxis Guidelines in Intensive Care and Internal / Units: A Retrospective Study from Palestine(2018-05-20) Ola, Wasef Omarya; Mohammad, Ismail Smerat; Dr. Rowa Al-Ramahi , Dr. Qusay Abdoh
- ItemAdherence to Stress Ulcer Prophylaxis Guidelines in Intensive Care and Internal / Units: A Retrospective Study from Palestine(2017-05-26) Mohammad Ismail Smerat; Ola Wasef Omarya; Dr. Rowa Al-Ramahi Dr. Qusay Abdoh
- ItemAdherence, attitude and Knowledge about influenza vaccination among medical personnel in Palestine(2019-05-10) رامي أنور منير مسك; ثائر ابراهيم أحمد صويلح
- ItemAlkanna use in Cosmetics and Medicine(2017-05-25) Basil Fuqaha; Ahmad Nawahda; Maha Assadi; Dr.Nidal Jaradat
- ItemAlloimmunization among dialysis patients in Palestine(2019-05-11) مرح صالح ابراهيم شلبي; وفاء عباس سليمان بني عودة
- ItemAllowing organ donation status among An-Najah National University students: a cross sectional study(2019-05-13) نوف أحمد أنيس أبو حسين; رواء عاص سرحان أطرش
- ItemAlterations of immunoglobulin G levels in the breast milk of mothers with exclusive breastfeeding compared to mothers with non-exclusive breastfeeding during 6 months postpartum in the West Bank(2021-06-30) Eman Alshawish; Farah abu hait; Anas ghayada; Nooraldeen rammal; Raya tell
- ItemAnalytical Method Development and Validation for Quantification of Ceftiofur Hydrochloride in Veterinary Oily Suspension Using HPLC Coupled with UV Detector(2021-05-31) Naser Shraim; Marah Ali Husain; Sae’d Mazen IDK; Amani Ismail
- ItemAnalytical Method Development and Validation of High-Performance Liquid Chromatography for Simultaneous Determination of Ibuprofen and Baclofen(2017-04-25) Aman Khasati; Aseel Ben Ali; Noor Souqi; Dr. Naser Shraim
- ItemAnalytical Method Development and Validation of High-Performance Liquid Chromatography for Simultaneous Determination of Oxytetracycline Hydrochloride and Flunixin in Veterinary Injectable Solution(2021-08-26) Rand Abdullah; Aseel Mansour; Mais Mansour; Naser ShraimA linear, precise, specific and accurate high performance liquid chromatographic validation method was developed for determination of Oxytetracycline and Flunixine in an injectable pharmaceutical dosage form (Fenox®). The purpose of high performance liquid chromatography (HPLC) analysis of any drug is to confirm the identity of a drug and provide quantitative results and also to monitor the progress of the therapy of a disease. The aim of the study is to develop and validate a liquid chromatographic method to quantify and determine two active ingredients simultaneously in one dosage form. The proposed method is rapid, cost-effective and can be used as a quality-control tool for routine quantitative analysis of these two active ingredients in the injectable dosage form. The HPLC analysis was performed on the phenomixc18, 15cm column, which was of a diameter of 4.5 mm and a particle size of 5 µm. Different mobile phases were then tested by using different mixture of ACN and buffer solution to obtain a suitable retention time and a pH 8.5. The UV detection was performed at the wavelength (λmax) range of 200-500 nanometers and the retention time of ocytetracycline 1.343 and flunixine 4.573 min. Analytical method validation was done in accordance to ICH guidelines. The linearity of the calibration curve was then established in the concentration range of 0.16-0.64 mg\ml of Oxytetracycline and 0.032-0.128 mg/ml of Flunixine. The mean recovery of 101.4 % -100.2%. The values of LOD Oxytetracycline 0.011949 flunixine 0.005281 and LOQ oxytetracycline 0.036209 flunixine 0.016003. According to the accuracy outcome results the RSD value for all Oxytetracycline samples is 0.283841 and for Flunixine samples is 0.304195, which represents good accuracy of the used method. As well the developed method showed excellent linearity, accuracy, precision, specificity, robustness, LOD and LOQ results within the acceptance criteria.
- ItemAnalytical Method Development for Sodium Valporate through Chemical Derivatization(2018-05-25) Nihaya Wasif Odeh; Ghadeer Naser Younis; Oyoun Fadel Zeidan; Dr. Murad AbualhasanBackground: Sodium valporate has anticonvulsant activity and is structurally different than conventional antiepileptic drug.Valporic acid lack conjugation in its structure and this makes it only detected a very short wavelength with low detection sensitivity . The objective of the study is to derivatized sodium valporate and introduce an conjugation to its structure to increase its absorbtion under UV detection range. The developed method can be adapted in routine analysis of valporic acid in pharmaceutical dosage as well as biological system.. Methodology: Sodium valporate was derivatized by adding a chromophore to its structure through introducing a methyl benzoyl or a phenyl group. Two reagents were used namely trichlorophenol and 2-hyddroxyacetophenone to introduce phenyl and benzoyl group to valporic acid respectively. The reaction used was estrification reaction using coupling agents. An analytical method was then developed and validated using reverse phase HPLC. The method was validated for parameters like linearity, range, accuracy precision and robustness. Results: The developed method was easy and feasible and can be applied to both routine analysis and bioanalysis. The method was very sensitive and could quantify valporic acid at a very low quantity. The developed method was found to be linear, accurate precise and robust. Conclusion: The proposed chemical derivatization and the developed analytical method is novel. The developed analytical procedure is the first of its kind, it is easy and feasible and can used to quantify and detect sodium valporate at very low concentration compared to other available methods available in the literature
- ItemAnatomic variations of the biliary tree in Palestine(2019-05-14) هبة مهند محمود عبد الكريم; مكرم لطفي "عبد الحميد" جبريني; رولا علي أمين علي
- ItemAntenatal corticosteroids and fetal lung immaturity in preterm birth(2017-05-09) ريته عماد فارس بطه; ريم محمود عوض ياسين
- ItemAnti-obesity Activity for 14 Wild Plants from Palestine(2016-04-20) Eyass Zuhair Zaghal; Maram Mahmoud Zaqzouq; Hadeel Jawad Aljammal; Dr. Nidal JaradatAnti-obesity activity was measured by using porcine pancreatic lipase inhibitory test which was established by using spectrophotometer method and used orlistat anti-obesity drug as appositive control reference. Results: The porcine pancreatic lipase inhibitory effect for organic and aqueous extracts of the studied 14 plants showed antilipase activity. Conclusions: The results showed that the studied plants have antiobesity activity, providing evidence for its folkloric use as functional food and medicine.
- ItemAntibacterial and Anticancer properties of Palestinian Asparagus(2018-05-26) Zaina Samer Barah; Zeina Wasfi Jarawan; Shahd Nedal Mahmoud; Dr. Nidal Jaradat
- ItemAnticancer activity of Holy Bramble plant(2019-05-25) Jalal Abu Asab; Khalil Obeid; Mohammad Sharabati; Dr. Nidal Jaradat
- ItemAnticancer Activity of Novel Amide Methoxyphenyl Derivatives(2019-05-25) Osama Hamoudi Eman Nawasra Abdullah abdelrazaq; Eman Nawasra; Abdullah abdelrazaq; Dr. Mohammad HawwashWorldwide, cancer is being the most killer disease, (1,1-2) 25% of the deaths in the 3rd world country are due to cancer. It has killed 9.6 million humans in 2018, out of 5 men, one is developing cancer during his life and for women the ratio is 1 out of 6. Many environmental factor as diet, obesity, alcohol consumption, physical inactivity, radiation, sunlight, viral infection and other genetic factors scratch together leading to this fateful disease. Over the years scientists invented a lot of treatments for cancer, each type of cancer is tried to be cured by its own therapy as chemotherapy, hormonal, radiation and surgery. Four compounds were synthesized as isoxazole-carboxamide. Characterized by HRMS, CNMR and HNMR. Compounds OAE4 showed potent anticancer against Hep3B cancer cell line. By further investigating their molecular effectors, it was revealed that compound OAE4 caused cell cycle arrest at the G2/M phase and it was close to Doxorubicin value as reference. In future studies, we can synthesize more analogues of carboxamide-Isoxazole derivatives as promising anticancer agents and further in-vivo investigations required to approve these effects and to design suitable pharmaceutical dosage forms from these compounds.
- ItemAnticancer, Antimicrobial, Antioxidant Properties and Preliminary Phytochemical Screening Of Dittrichia Viscosa (L.) Greuter, Taraxacum Cyprium H.Lindb. and Eruca Vesicaria (L.) Cav.(2016-04-30) Aya Tamimi; Abdullah Almasri; Waleed Abu Najeeb; Dr. Johnny AmerBackground Background cancer  has become a serious, global concern, and so the discovery of novel antioxidant and antimicrobial from herbal sources may provide anticancer and valuable solutions for this problem. Actually, replacement of harmful chemical antioxidants with natural ones may prevent various diseases. The present investigation describes for the first time the antioxidant , phytochemical screening , Anticancer  and antimicrobial activities of aqueous and organic extracts to the roots of  Dittrichia Viscosa, Taraxacum Cyprium and Eruca Vesicaria . Methods: Free radical scavenging property was analyzed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, while antimicrobial activity was tested against the selected strains from American Type Culture Collection (ATCC) and clinical isolates such as Shigella sonnie, Staphylococcus aureus, Enterococcussfeacium, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Epidermophyton floccosum and Methicillin Resistant Staphylococcus aureus (MRSA), and using minimum inhibitory concentration (MIC) assay. Results: A mixture of phytochemical compounds was found in all of the studied extracts which also showed remarkable potentials of antioxidant , and antimicrobial activities. The current study provides initial data that justify the use and importance of these plants in Palestinian traditional medicine. Conclusion: This study provides evidence that the aqueous and organic extracts from the roots of Dittrichia Viscosa, Taraxacum Cyprium , and Eruca Vesicariaexhibited interesting antioxidant activities when compared to Trolox ,
- ItemAntimicrobial and Anti-cancer Activity of Purslane: An Experimental Test of its Oil Mechanism of Action(2021-05-07) Ihdaa` Ibraheem; Batool Salman; Siwar Nashif; Ahmad Eid